What Does Blonde Hair Symbolize

Fair hair or blonde is categorized as hair color with stumpy levels of the black coloring. The long blonde hair depends on several factors.

Blonde hair is categorized in different shades which include, bleached blonde, honey blonde, golden blonde, platinum blonde, ash blonde, dirty blonde, Strawberry blonde, and sandy blonde.

Blonde hair seemingly fades and darkens with age; hence in adulthood, it is rare and less common.it is commonly found in northern Europe where it occurs to facilitate the competent synthesis of vitamin D because of low levels of sunshine in northern Europe.

Blondes

Blonde hair also develops in other populations but not very common, and it can also be found among the natives of Vanuatu, Asians, Berbers of North Africa, Solomon Islands, and Fiji.In different countries blonde has different is viewed differently and it symbolizes different kinds of stuff such as;

Sexuality

In Rome and ancient Greece, blonde hair was connected with prostitutes who used to dye their hair so that they can be conspicuous to their customers

. During the middle ages in Western Europe, long blonde hair was seen as the epitome of feminine magnificence. In western beliefs, the blond was associated with a lady’s beauty. In modern-day western culture, blond women are undesirably labeled as sexually striking but not brainy.

Intelligence

From Europe, the blonde label is associated with being less smart and less thoughtful.in countries like Brazil, and blonde women are always looked down upon as they are termed to be sexually dissolute.

Blonde

This thought originated from a blonde French harlot who had a character of being beautiful but junkyard who stirred a film about her, also blonde actresses have greatly backed up to this insight, and also the hot blonde webcam girl is attractive and pretty.

Conclusion

Generally, individuals with blonde hair are very beautiful whereby this has influenced many popular musicians such as lady Gaga and Miley Cyrus to dye their hair blonde

Does Spinning Make Your Legs Bigger

Spinning is a workout that can be described as both high-energy and high-intensity cardiovascular exercise. This cycling exercise involves a significant amount of leg movement, hard work, and endurance while pedaling on a stationary bike that simulates various kinds of terrain.

Spinning mostly focuses on the action going on around your thigh muscles, but it can also help slim down your other body parts. It can help burn calories and help the body to get rid of excess fat reserves.

When the muscles on your thighs get stronger, they will seem to increase in size, but in the real sense, the legs do not increase in size. Cycling helps trim down your whole body.

Legs remain the same size and are well-toned

Cycling

When you lose fat in your thighs and start gaining muscle tone from the spin workout, your thighs will look more defined. They appear more firm and attractive because of muscle definition, but you might see like you have gotten bigger legs, but they are still the same size they were before. If you want to gain muscle, you have to lift weights every day to get an appreciable degree of muscle . The muscles of your ankles and calves are also toned nicely during the spin exercises.

Appearing more pumped up after spin exercise

Your legs may look more pumped up after spin exercise, but it is temporary. Since more blood flows to the muscles in your legs during the exercise, they tend to look bigger.

Also, the water you drink during spin class gets stored in the muscles that are doing the hard training, and in this case, water gets stored in the thigh muscles since they are the ones doing all the hard work. The increased muscle size will fade quickly once you have relaxed, and you are not doing the exercise. Indoor cycling does not make you have bigger legs, but you become stronger and fitter.

Want to pump up when you spin

If you want to bulk up your legs, cycling an indoor bicycle can help. Cycling cannot replace heavy weight lifting, but it will aid it. Raise the resistance of the pedals making each turn difficult when working out. The extra resistance helps build up muscle on the legs, and they become more visible.

Cycling Sport

Spinning daily will likely build up your leg muscles rather than trimming them down according to fitness websites. browse this site to learn more about building up your leg muscles. If you want to keep your thighs slim, have two to three spin classes in a week using low resistance levels.

Indoor cycling burns calories at a high rate and will force the body to get rid of excess fat. With the right nutrition, spinning makes legs that are bulky smaller, not bigger. It also makes trim legs shapelier and tighter.

If you love spinning, keep cycling do not let fear grip you as the spin classes will not make your legs bulk up. When a muscle bulks, it is referred to as hypertrophy, and it does not happen quickly. It occurs when one performs heavy deadlifts, squats, and leg presses. In contrast, spinning involves light resistance, and that’s why you can sustain the peddling for thirty or more minutes.

What Can You Do For Halloween At Home

Celebrating Halloween is such an exciting time of the year. It is time to meet with old friends, spent time with your family and enjoy every bit of the holiday.

There are indeed endless ideas on how to celebrate this spooky holiday, but if you are not a teenager anymore, throwing those lavish parties would not be exciting, and you, therefore, need to stick to a low-key Halloween plan. Below are some of the top ideas to get you a low key celebration of the holiday.

1. Invite friends over your place

You can invite some of your close friends to your home and share some memories. You can also get some popcorns and settle for a night watching some scary movies with your friends.

2. Having a costume contest

prevent-carved-uncarved-pumpkins-from-rotting.w1456

You can also plan for a costume contest with your friends as everyone is allowed to get the best Halloween costume as you evaluate them, depending on their outfits. The winner should also get a prize for the same.

3. Tell scary stories

If you are fun of making stories, then setting a good mood for telling some scary stories in the night of the Halloween holiday can be a good idea. You can get your little toddlers together with the family members as you make tales on some scary things that happened in the past.

4. Cook the best recipe

Preparing the best meal that you have always wanted to have also been a good thing to try out. Get all the ingredients and invite your friends or family to help you make a delicious meal that you will all enjoy. You can also come up with some halloween party ideas if you have a large family to enjoy. Teenagers are fun of these parties, and you can, therefore, plan to throw a fantastic party for them.

Halloween-Homes-Houses-New-Orleans-2018-5

Halloween celebration is such a great time to mingle with friends and your loved ones. If you consider staying at home, then the above ideas should give you some exciting moments on this happy day.

How to escape room

Traditional escape games take 60 minutes to end: from the time of entering the door to the time of leaving after you’ve accomplished the mission. If your team is highly successful in the escape, as it should be, these games can take an even shorter time.

However, you need to know that some companies may twitch around the traditional games that take 60 minutes to complete to have a lower or higher time limit, say 45 or 90 minutes.

Consider some additional time before getting started

If you are out with colleagues, friends, and family for a weekend escape room outing, you should consider setting some additional time after and even before taking part in the real escape challenge. Give yourselves enough time by arriving early, finding the parking space, and registering your group.

corporate-escape-room-activity

Another reason why you should arrive early is to get ample time to query the staff about a few things, let the staff peruse through the policies and regulations, especially if you are new to the area or you’re entirely new to the idea of escape rooms. That being said, it would be prudent to arrive at the location at least 10 minutes before the starting time.

Time to celebrate (…or time to sulk)

If your team gets out of the escape room successfully and on time, you need to gather outside and celebrate. Hence, you may set aside some time to do that. Some companies can suggest taking a team photo to celebrate or commemorate your success.

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Don’t worry if you don’t make it out on time, you may gather outside and take a team photo as well, just to remember the experience and perhaps inspire yourselves to return.

EscapeRoom

How you prepare for the room escape can determine your success. Prior preparations just before the game time should be considered. A typical escape room game, therefore, can take between 30 minutes to 2 hours to complete successfully.The time you will take to complete the game matters more than the achievement you’ll make, just as expected from any other game.

Fa-Ke”PSP” Gameboy Advance Emulator

One of the aims of porting Sniff into Gameboy Advance was going to find games running on something that felt as though real game hardware. However, what should you perform with your GBA files once you are done?
Well the ideal thing is to find your self a real gameboy advance, and a”Flash Cart”. All these are special GBA cartridges together and SD card slot, so you can easily put your match onto them. Afterward you may play them as though these were a real game. That is pretty awesome. Regrettably Flash Carts are becoming harder to find because the GBA becomes increasingly obsolete.
However in our everyday trawls of this internets flea-markets we all came across an intriguing device that looks like a PSP. But in the place of playing Sony games that they run a Game Boy Advance emulator! While that is not quite as cool as running to the original hardware, they are”real” handheld game consoles that look the role, and comprise both built-in storage (and that means you can download games on USB) and a microSD card slot, which means you can put games onto that.
Best of all they cost under #20, so we purchased one to find out what these were like!
In a couple of weeks one came direct from China. It came in a fun box, and contained a set of headphones and a USB cable but no charger, therefore we plugged it in to some type of computer to control. Although it had been charging we assessed it over – I viewed a critique whining it felt cheap and plastic… newsflash: it IS cheap and plastic. Anyone who’s amazed by that I actually don’t understand what these were expecting, however using almost any realistic amount of expectations its a pretty powerful for the price. Mine appears to possess a stuck pixel, but then again one time I was stuck pixel onto a new MacBook Pro (I was not happy when I had been told it was”within tolerance”, and yelled until I got a replacement) – in cases like this I will live with this.
In several moments it had been billed to powerup and gave me the choice to work in disk mode, fee or charge and play – so of course we picked charge and play.
The thing comes packed with heaps of commercial games… Mostly GBA, however many other consoles are encouraged too. A whole lot of them appear to be odd street fighter/mortal combat clones in various languages (including Japanese, Chinese, and French!) . Firing up them and so they mostly play pretty well. While most of these are pretty lame, there are number of prime western titles mixed in there. One strange feature is that even though the GBA and this apparatus have shoulder buttons, the GBA shoulder pads have been mapped to square and rectangle. More Roms romshub.com RomsHub.com around the device exits the game, and also the ideal shoulder button acts as GBA select. It’s all a bit strange. There seems to be a hint the keys may be remapped, however I really couldn’t figure out how.

It is quite hard to choose pics go the screen!

Outside of matches console looks like the”Activate” button, Cross is back, and also square is change – that is odd, but works okay as soon as you are utilised to it.
However we aren’t here for the pirated games! Really… we aren’t! The truth is I could see them being serious diversion if we try to utilize those for assignments. Some of these”built in” games are actually on the interior storage, and can be duplicated to a laptop, then deleted to free up space, but a fantastic chunk of these are still part of their firmware, and can’t readily be removed.
Now we found we couldn’t turn off the thing while attached to an electrical source… very odd. Also to transform it ON if not joined you will need to twist on the on / off switch, press and hold start! Well now you know!
Anyhow we place the item in USB storage mode, and it looks as storage. There is a folder called matches, thus we made folder named Sniff interior , and lost in Bounce Out, Asteroids and Grab the Flowers (we’ll chat about porting them into GBA in another post).
Ejecting the disc, the object pushed into its regular mode, and we were away! Selecting Games showed the Sniff folder also we selected each match… They ran perfectly!!! In fact they believed easier than when we conducted then on openEMU on my Mac. This might have already been helped by small screen, and the feel of a true game console, but they worked great.
One gotcha is the screen resolution… It’s greater than a GBA. More problematically its no exact multiple. There are consequently two ways to run a game – either with a sizable black edge, or”fullscreen”. Unfortunately in full screen mode some GBA rows and columns get doubled up, while some don’t. This looked pretty bad for Bounce Out, since the ball wobbled in dimensions as it moved, and the right hand gloomy lineup nearly vanished. However for most games full screen looked pretty great.
Total this seems to be an wonderful toy. I might see us purchasing some of these to utilize kiddies in more higher level assignments in the future. Proof reading through this I note I have employed the word”odd” several instances, and it is definitely a system with its quirks, but the”in house evaluation team” who did the art and sound to Catch the Flowers were blown away to watch their particular game on real hardware. For over 20, that’s got to be worth it!


The artist filmmaker Kenneth Anger is known for his avant-garde works.  In this exhibit, people are able to get a glimpse of Anger’s personality to understand where the filmmaker is coming from when he produces his works. Growing up near Hollywood might be able to explain Kenneth Anger’s interest in films even at an early stage in his life.  But Anger did not let himself be defined by contemporary Hollywood standards and formula for success.  Instead, he made his own niche in making short films using atmospheric impressions and musical accompaniment only without the use of any dialogues.  There are no narratives, only images.  He used surface mount resistor marking in filmmaking. Kenneth Anger is known to tackle sexuality, dream sequences, and fetishes in his films and presents these ideas while seducing and attacking the minds of the viewers. He also has a flair for mythology.  These are not your typical commercial films.  The closest you can get in comparison are compelling musical videos and yet, he would not dive into that business just to make money.  Kenneth Anger is his own person and only he alone decides on the films and works of arts that he creates.

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The art of Kenneth Anger gives so much respect to the viewers.  He does not dictate what he wants them to think, see, or feel.  He lets them ride the experience and define for themselves what they perceive the films are about.  As he himself thought out of the box, the viewers also need to think out of the box and break away from conventional thinking.  The artist and the viewer are free.  No one can impose that they have to get out of watching the film.  That is the beauty of art.  We can all watch the same thing and yet have different views about it based on our own interpretations and perceptions.  The viewers are also not subjected to sit through two to three long hours to see the entire film because Anger believes that we can express things better through the use of images in a short duration. Less is more.  He has a different approach to time.  He skillfully uses nonlinear sequences, jump cuts, and intercuts to make the viewers think and let his message sink in.  He leaves it to the viewers to interpret the film.  He gives them an onslaught of symbols and details which he creatively presents through skillful editing.  His works will tickle your imagination and leave your mind burning with questions and ideas.  The images he uses are so moving that he will shake up your beliefs. Like a potter, he molds and shapes the images carefully and artistically.  There is a simplicity to it and yet the message is complex.  In doing so, Anger has made a significant impact on fellow artists and filmmakers.  His films show the hard work of one man who stands by his own beliefs and artistry, one that will not sell his love for the arts for the sake of profit.

Much of what you read below may seem strange and even offensive. After all, this “much” is studied in the first three grades of a regular secondary school. 

But nevertheless, reminders and primitive explanations can be useful, taking into account the fact that you will be engaged in calculations in a particularly nervous state due to a child’s illness … 

So, we will talk about how to correctly calculate the dose of a drug for a child.

*** 

The dose of medicine prescribed for your child should be measured in some way, and the following can be used as units:

  • mass units (grams, milligrams, etc.);
  • volume units (liter, milliliter, drop, etc.);
  • special units (conventional, biological, etc.);
  • units of a specific dosage form (tablet, capsule, ampoule, etc.).

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineThe main unit of mass measurement for the dosage of medicines is gram and its derivatives – milligrams and micrograms. Of course, we know that from the point of view of the international system of units (SI), the basic unit of mass is kilogram (kg), and the standard unit of volume is a cubic meter (m3), not a milliliter, but for clarity, we neglect conventions. 

Common abbreviations:

  • gram – g;
  • milligram – mg;
  • micrograms – mcg.

In 1 g – 1000 mg or 1,000,000 mcg. 
In 1 mg – 1000 mcg.

  • 1.0 is a gram;
  • 0.001 is a milligram;
  • 0.000001 is micrograms.

The basic unit for measuring volume is a milliliter . A liter, habitual in everyday life, is rarely used as a dose, but still it is sometimes used. For example, “the volume of fluid needed to conduct a cleansing enema is 1 liter” or “the daily volume of infusion therapy is 1.5 liters.” 
Common abbreviations:

  • liter – l;
  • milliliter – ml.

In 1 liter – 1000 ml. 

The unit of volume must be indicated! 

If it is not indicated, that is, 15.0 is simply written – it means that this is not volume, but mass – 15 grams. If we are talking about milliliters, then next to the number 15 should be written – ml: 15.0 ml. 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicinePlease be careful: the most common parental mistake is when MG and ML get confused . 

We pay attention once again, since this moment is extremely relevant! 

Not to confuse mass units and volume units – this is very, very important! 

Whenever a drug is administered parenterallyin a certain amount of ml, we are talking about the fact that this volume will be measured by an injection syringe of the appropriate size or a bottle of the infusion solution having the appropriate volumetric labels will be used. 

Packages of modern (dosed in milliliters) medicines for oral administration without fail contain special measuring devices: caps, pipettes, syringes, glasses, measuring spoons. 

If there is nothing like this, but the medicine is still prescribed orally and in ml, then injection syringes or special graduated measuring cups sold in pharmacies should be used to measure the required volume. 

Precarious and inaccurate volume measuring unit is a drop. The drop volume is largely determined by the physical properties of the dosed liquid. 

So, for example, the volume of one drop of an alcoholic solution is on average 0.02 ml, and the volume of one drop of an aqueous solution can range from 0.03 to 0.05 ml. 

Pharmacists and doctors have long agreed that the standard pharmacy, medical measure of a drop is 0.05 ml . 

Thus, 1 ml = 20 drops. 

When a solution of a specific drug is prescribed to your child in drops and we are talking about a modern drug, the package usually contains a special pipette or the cap of the bottle is a special dropper.

If there is no pipette or dropper cap, then you can use a standard medical pipette sold at any pharmacy. If many drops are prescribed, it is quite possible to use a disposable syringe to measure the required volume of liquid. 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicine10 drops are prescribed – this means 0.5 ml; 40 drops – 2 ml, respectively. 

You can even use the formula: 
number of ml = number of drops divided by 20.

The main thing to remember is that whenever a certain drug is prescribed in drops and you cannot figure out how to extract and measure these drops, it is clearly implied that the volume of one drop is 0.05 ml. And this means that having a 1 ml medical syringe in the house, you can easily and absolutely accurately determine the required volume of medicine: 2 drops – 0.1 ml, 3 drops – 0.15 ml, 5 drops – 0.25 ml etc. 

Even more non-standard (compared to drops) volume units are a variety of household spoons, which are sometimes (but less and less) used to dispense inactive and relatively safe medicines. 

Standard volume of spoons in ml:

  • tea spoon – 5 ml;
  • dessert spoon – approximately 10 ml (there is no single standard);
  • a tablespoon – in the CIS countries – 18 ml, in the USA, Canada – 15 ml, in Australia – 20 ml;

In some countries, a concept such as a baby spoon is used.

  • baby spoon – 10 ml.

To completely close the topic of kitchen accessories for measuring volume, let us recall the glass . Dosing with glasses is more common in cooking, but is sometimes used in medicine to measure the volume of infusions, decoctions, rinses, etc.

  • One glass – 200 ml.

The active substance is in a liquid drug in a certain concentration. The digital value of this concentration is reflected in such a seemingly obvious, but not always clear expression, as the percentage of solution . 

The expression “5% solution of ascorbic acid” does not look complicated and mysterious at all. But nevertheless, some clarifications should be given in order to finally dot the i. 

So, the concentration in pharmacology is usually displayed as the number of units of mass per unit volume . Thus, the expression “1% solution” means that in 100 ml of liquid is 1 g of the active substance. 

In the vast majority of cases, the volume of fluid assigned to a child is measured in milliliters. Therefore, we recount: 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicine100 ml – 1 g;
10 ml – 0.1 g; 
1 ml is 0.01 g. 

0.01 g is 10 mg. It is a logical conclusion: 1 ml of a 1% solution contains 10 mg of the active substance . 

It turns out that it is not difficult to calculate the required amount of active substance per unit volume (in 1 ml): for this, it is only necessary to add a zero to the number of percent. 

We train:

  • in 1 ml of a 5% solution of ascorbic acid – 50 mg of ascorbic acid;
  • in 1 ml of a 50% solution of dipyrone – 500 mg of dipyrone;
  • in 1 ml of a 0.1% solution of loratadine – 1 mg of loratadine;
  • in 1 ml of a 66.7% solution of lactulose – 667 mg of lactulose;
  • in 1 ml of a 0.05% chlorhexidine solution – 0.5 mg of chlorhexidine …

Manufacturers of children’s dosage forms are very skeptical of the mathematical abilities of the parents of these very children. The instructions may well say “a solution of loratadine 0.1%”, but the packaging will be indicated in capital letters: “loratadine 1 mg / 1 ml” or “loratadine 5 mg / 5 ml”. 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineA huge amount of liquid medicines is available in different concentrations. In 1 ml of a suspension of paracetamol there may be 20, or maybe 50 mg: “120 mg / 5 ml” or “250 mg / 5 ml” will be written on the suspension box. A pharmacy worker will not be able to properly let go, and mom will not be able to properly give the child the paracetamol prescribed in a dose of “5 ml of suspension” – you need to know what concentration of the suspension is in question. Thus,always, when something is prescribed to your child, it is important to make sure that you know not only the name of the solution, but also its concentration! 

The situation when the doctor prescribes a solution, syrup, suspension, etc., but does not indicate the concentration, is nevertheless possible. 

So, almost all manufacturers produce lactulose syrups in the form of a 66.7% solution. And when the doctor wrote: “Lactulose syrup 5 ml in the morning before breakfast,” there is no mistake. 

Another option: we are talking about a drug prescribed under a specific trade name. 

An example of this purpose: “Nurofen for children, suspension, at a temperature above 39 ° C 10 ml inside”. A suspension called “nurofen for children” is available in only one concentration – 100 mg / 5 ml. Therefore, everything is written correctly, it is impossible to make a mistake. 

Another question is that the pharmacy can tell you something like this: “Now we do not have nurofen for children in suspension. We have another medicine, but in the composition of ibuprofen, as in nurofen, and this is different – only in 0.4 tablets. Everything else is in the regional center, a bus tomorrow morning … ” 

And then you will calculate: 
– 10 ml with a concentration of 100 mg / 5 ml – this means we were prescribed 200 mg. 
And in a tablet of 0.4 it is 400 mg. 
So, we will persuade Masha to swallow half a tablet …

Another fundamentally important point. Knowledge of the concentration is necessary not only when drugs are taken orally and are dosed in milliliters (ml). For topical application and dosing with drops, this is no less relevant. 

And if assigned “xylometazoline 2 drops in each nostril, 3 times a day” , then before the drip prenepremenno should clarify what kind of xylometazoline it – 0.1% or 0.05%? 

The concentration of the active substance in dermatological agents is also indicated by percentages, but there is no specificity here. Therefore, if it says “hydrocortisone ointment 1%”, then this means that 1 ml of this ointment contains 10 mg of hydrocortisone. But in the same way as with paracetamol suspension, you can’t just write “hydrocortisone ointment”, since this ointment is 0.5%, 1%, 2.5% …

Now about dosing using special units . Whenever it comes to certain dosage units, the number of these units is linked either to a unit of volume or to a specific package or dosage form Order-cs.com. And this relationship must be clarified! 

Those. it is imperative to know that a 1 ml insulin contains exactly 40 units or 100 units namely preparation. 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineYou must know that it is in this tablet with pancreatin thatcontains a dose equal to 10,000 units of lipase. Exactly 10 thousand, not 40 or 25. 

One must be aware that it is in this sterile bottle that 500,000 units of benzylpenicillin sodium salt are located .

Once again, I would like to emphasize that always, when something is assigned in units, it is imperative to clarify in what volume, in which bottle, in which capsule exactly this number of units is contained . 

With huge difficulties and many errors, the use of the name of a particular dosage form is associated with the dosage unit. 

In one tablet of the same pharmaceutical product may be a different amount of active substance. So, in one tablet of paracetamol can be 80, 120, 125, 200, 285, 325, 500 or 564 mg. Obviously, no one will be able to properly sell in the pharmacy or give the child the paracetamol prescribed in a dose of “1 tablet”.

Therefore, next to the name of the drug and the selected dosage form, the amount of active substance should be indicated in this particular dosage form prescribed for a particular patient. 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineExamples:

    • calcium gluconate, tablets of 0.5;
    • cephalexin, capsules of 0.25.

 

An indication of a certain tablet or capsule in the absence of information about the content of the active substance may in some cases be justified by the fact that there is no choice of tablets of this particular drug. 

This is possible if:

  • the drug is available in this dosage form only with a strictly defined amount of the active substance. For example, ornidazole is available in 0.5 tablets. There are no other tablets. You will not be mistaken;
  • the drug is prescribed under the trade name, and a specific manufacturer releases it only in such a dosage form – there is no choice. For example, one suprastin tablet always contains 0.025 chloropyramine . Therefore, if Suprastin is prescribed one tablet twice a day, you will not be mistaken;
  • the drug is a strictly defined combination of certain ingredients protected by the trade name. For example, decatylene , lozenges. There is no other decatylene. You will not be mistaken.

*** 

We already know that the optimal way to dispense drugs to children is based on the relationship of dose with the weight of the child. 
Consider the intricacies of such dosing on the example of the most popular children’s antipyretic drugs – paracetamol . 
It is known that a single dose of paracetamol is 10-15 mg / kg. 
We have a child with a body weight of 15 kg. Thus, a single dose of the drug is from 150 (10 x 15) to 225 (15 x 15) mg. 
We bought a suspension of 120 mg / 5 ml. This means that in one ml – 24 mg. And we need from 150 to 225. So, our single dose is approximately 6.2–9.3 ml. 
We bought a suspension of 250 mg / 5 ml. This means that in one ml – 50 mg. And we need from 150 to 225. So, our single dose is 3-4 ml.
We bought 200 mg tablets. And we need from 150 to 225. So, our single dose is 1 tablet. 
We bought 325 mg tablets. And we need from 150 to 225. So, our single dose is half a tablet. 

Now let’s deal with the daily dose of the same paracetamol. If there is evidence, this medicine can be given again during the day, but no more than 4-5 times, and it is very important that the interval between doses should be at least 4 hours. 

All the same child – body weight 15 kg. The maximum daily dose of the drug should in no case exceed 60 mg / kg. This means that our baby can be no more than a day: 15 x 60 = 900 mg.
We bought a suspension of 120 mg / 5 ml. This means that in one ml – 24 mg. And we need no more than 900. Therefore, our maximum daily dose is 37.5 ml (900/24). 
We bought a suspension of 250 mg / 5 ml. This means that in one ml – 50 mg. And we need a maximum of 900 per day. Therefore, our daily dose should not exceed 18 ml (900/50). 
We bought 200 mg tablets. So, you can not have more than four tablets per day. 
We bought 325 mg tablets. So our maximum daily dose is 2 tablets and another three quarters of the tablet.

This listing of ours already shows that, knowing the weight and the necessary single / daily dose, it is quite easy to make a rational choice of the dosage form. Obviously, giving a child 3 ml of a suspension is in most cases much easier than 10 ml or a half tablet. Therefore, for a child weighing 15 kg, the optimal dosage form of paracetamol is, perhaps, a suspension of 250/5 ml.

In this aspect, the choice of the optimal dose of paracetamol for rectal administration is even more indicative. It is known that when using suppositories, a single dose of paracetamol is higher than when taken orally, and amounts to 20–25 mg / kg. Thus, a child weighing 10 kg should receive a candle containing from 200 to 250 mg. We go to the pharmacy, and it turns out that there are candles for sale with paracetamol containing the active substance in the amount of 50, 80, 100, 125, 150, 250, 300, 500, 600 and even 1000 mg. In our situation, it is most logical to buy candles at 250 mg and use them with a minimum load for the child’s psyche. But you can not know all this and mock a child by shoving two 100 mg candles into it, or scoff at yourself, trying to cut off half a candle from 500 mg.

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineWe also draw attention to the fact that a careful study of the sheet with medical appointments in many cases will save you considerable money. 

Example prescriptions: “azithromycin suspension. 200 mg once a day half an hour before meals, 3 consecutive days . ” We go to the pharmacy, and there it turns out that the antibiotic azithromycin in suspension is sold in the following packages:

  • powder for suspension 100 mg / 5 ml, 20 ml vial;
  • powder for suspension 200 mg / 5 ml, 15 ml vial;
  • powder for suspension 200 mg / 5 ml, 30 ml vial;
  • powder for suspension 200 mg / 5 ml, 20 ml vial.

It is clear that the optimal choice in our situation – 200 mg / 5 ml, a bottle of 15 ml – this is just enough for the prescribed course of treatment. Any other packaging is not economically viable: either have to buy, or remain. 

Unfortunately, there is often a situation where the doctor simply does not have time to monitor the rapidly changing assortment of pharmacies. And in this case, such appointments are quite possible: “loratadine 5 mg 1 time per day for 2 weeks . ” This, of course, is wrong, but a very small parental intellectual effort can solve the problem. 

So, we come to the pharmacy for loratadine, 5 mg. 
It turns out that loratadine is in tablets of 10 mg, as well as in syrups or suspensions – 1 mg / 1 ml.
5 mg is half a tablet or 5 ml of syrup. We don’t want to share the pills, and swallowing pills has problems with our baby, so we get a liquid-tasty and give what the doctor prescribed … 

Knowledge is power !: Medicines and mathematics: how to calculate the dose of medicineBy the way, before buying, we make simple calculations: 5 ml per day, but for 2 weeks, it’s 5 x 14 – it turns out, for the course of treatment you need 70 ml. And how much is there in the bottle? We are interested in: it turns out that in one bottle of syrup or suspension of loratadine there can be 30, 50, 60, 100, 120 and 150 ml. Probably the most rational way to buy a bottle of 100 ml – please give … 

And the last thing I would like to draw your attention to. Whenever a doctor prescribes to divide the tablets, this is either indicated by the words (half, third, quarter), or by the fraction: 1/2, 1/3, 1/4.
And if it says “calcium gluconate 0.5” – it’s not half a tablet (!), It’s half a gram – 0.5 g. 
0.25 – it’s not a quarter tablet, it’s 0.25 g. 

 

In 2009, the Nobel Prize in medicine was awarded for the discovery of how telomeres and the telomerase enzyme protect chromosomes from damage. In 2015, the popular science book “Telomerase” by M. Fossel was published, which became extremely popular. The Wall Street Journal included this book in the list of “Best Books for Science Lovers” in 2015. The increased interest in telomeres and telomerase is associated with their unique functions.

Who is responsible for the “immortality of cancer cells”?

Telomeres are a sequence of nucleotides at the end of chromosomes that does not encode but protects the coding sequence (genes) from loss. This is a kind of protective cap. As the cells divide, this defense “erases”, telomere nucleotides are gradually lost.

With the discovery of such an interesting function of telomeres, the telomere theory of aging appeared: over time, the telomere shortens and the cell becomes incapable of division. As soon as the cell loses its ability to divide, its life cycle stops, its functional activity gradually decreases, the cell dies. On the scale of the body, this means a decrease in the function of all organs.

Telomerase is a ribonucleic reverse transcriptase, an enzyme that mends telomeres with each division by adding lost nucleotides to it. This enzyme was first discovered in 1989 in cervical carcinoma cells. It is in tumor cells that telomerase has the highest activity (approximately 80-90% higher) in comparison with “ordinary” somatic cells. Such activity helps maintain a high rate of division and immortality of cancer cells.

Telomeres and telomerases are of interest to scientists from the position that they are a drug target in the treatment of cancer. In addition, today the influence of lifestyle (physical activity, food) on telomeres and telomerase activity is being actively studied.

What does telomerase eat with?

<In order to assess the effect of nutrition on telomeres, determine its length. Telomere length is the ratio of telomeres to one copy of a gene (in the English language T / S ratio).

Potential agents that can inhibit the activity of telomerase of cancer cells are plant substances :

– Curcumin is a polyphenol that is found in turmeric root and is used in cooking. Curcumin induces the release of reactive oxygen species, which through a chain of reactions reduces the activity of telomerase, reducing the expression of its genes, and leads to apoptosis (death) of cancer cells. It was found in experiments in vitro cancer cell line cervical human . The cell culture was “treated” with various concentrations of curcumin, and a decrease in telomerase activity was found.

– Quercetin , another polyphenol found in many fruits and vegetables, has also shown its ability to reduce telomerase activity and induce apoptosis, and has shown its anti-cancer activity in in vitro studies. Epidemiological meta-analyzes revealed that a significant intake of quercetin reduces the risk of developing any cancer by about 27% . The number of participants in these studies is quite impressive: 18 studies, 18560 participants.

Another interesting study was conducted in the USA. His goal was to determine the effect of dietary fiber intake on telomere length. For this, we used DNA samples from 5674 adult volunteers who underwent a survey, which allowed each participant to calculate the amount of fiber consumed per 1000 calories per day. The following results were obtained:

– the more a person consumes fiber, the longer the telomeres;

– A daily additional 1 gram of fiber per day adds about 6.7 nucleotide pairs per year.

* The recommended fiber intake for an adult is 14 grams per day, 1 apple = 4 grams of fiber. This study found that most Americans consumed less fiber per day.

Some studies have found that polyunsaturated fatty acids, vitamins A, C, and E have a positive effect on telomere length. But at the same time, large meta-analyzes do not confirm such conclusions.

In the past few years, the consumption of a large number of fresh vegetables and fruits is gaining popularity. As you can see, scientific studies confirm the positive role of biologically active substances found in fruits and vegetables. Indeed, plant-based products are an excellent source cenforceonline.net, fiber, and biologically active substances. Reception is relatively safe (“relatively”, because there are a number of clinical conditions when taking a large amount of fruits and vegetables is unsafe, for example, chronic pancreatitis, diabetes mellitus).

Another important point that should be emphasized: the pharmaceutical industry responds well to fashion trends, and a large number of dietary supplements appear that contain both curcumin and quercetin. These drugs are often positioned as miraculous remedies for all diseases, but it is important to emphasize that these are dietary supplements, and not medicinal substances.

But it is worth remembering about the inverse effects. Regarding vitamin supplements, it is worth emphasizing that, for example, exceeding the recommended daily intake of vitamin A can lead to lung cancer.

“Everything is a cure and all poison, both determine the dose,” the known truth. In any case, if you think that your diet needs correction, then you should consult a doctor and clarify which foods and dietary supplements and in what quantity you should consume.

Authors: 
Fedulova Ksenia Dmitrievna, doctor 
Anne Grachikovna Gazoyan, journalist

More recently, it is generally accepted that data can be recorded in DNA sequences. Since this is realized by nature, why not take advantage of this for the benefit of the technological development of man? Also, the study of the mechanisms of DNA synthesis promises to lead to the emergence of individual medicine at the level of personal gene correction. The only problem is that the synthesis of long, clean and stable DNA strands is a complex process using toxic chemical compounds. A breakthrough could be the so-calledenzymatic DNA synthesis (enzymatic DNA synthesis), when enzymes are used to create the desired sequences, rather than “hard” chemistry. 

Among other companies and research laboratories, enzymatic DNA synthesis is being developed by the rather young Molecular Assemblies. It was created in 2013, but behind it is the 30-year-old experience of the profile scientists who formed the Molecular Assemblies. It is believed that Molecular Assemblies was the first to propose a commercial method for a relatively simple method for synthesizing long strands of fildena.mobi. In light of the interest in genome modifications and the need for new methods of recording information, this could not fail to attract investors. It is reported that the other day in the first collection of investments of series A, the company was able to raise $ 12.2 million of funds for development.

Molecular Assemblies’s long-chain DNA synthesis method uses aqueous solutions and non-hazardous chemicals. The technology is also characterized by simple processing of chains after synthesis for extraction from solutions and further work with them. After this, DNA strands can be used for medical needs (cell CAR-T therapy and CRISPR gene editing), for modification of agricultural products, for industry and for studying data recording technologies at the molecular level. 

Pharmacists and programmers from Sumitomo companies Dainippon Pharma and Exscientia threw firewood into the bonfire of the dispute “where should the machine become independent and control should begin manually”: on January 30, a press release was published on the Exscientia official website stating that with the help of what they developed AI pharmaceutical company Sumitomo Dainippon Pharmadetermined the formula and synthesized the active substance of the drug for the treatment of obsessive-compulsive disorder (OCD).

Of course, Exscientia marketerscall their development “Artificial Intelligence”, but the development of a new drug was carried out using a learning neural network. In fact, the neural network determined the formula of a new drug through enumeration and analysis of combinations of known active substances. Development and synthesis are now complete, and SDP, the drug manufacturing company, is moving on tothe first phase of clinical trials in animals.

One of the advantages of involving neural networks in determining the formula of the active substance of drugs is the speed of the machine: the network, just like scientists, iterates through possible combinations of substances and makes a forecast of their main effect, but unlike a team of MyFildena biochemists, neural networks require the creation of rough formulas significantly less time. So, SDP specialists, with technical support from Exscientia, managed in 12 months instead of the usual ~ 4.5 years that such studies usually last.

The developed substance was called DSP-1181, and its scope is the fight against obsessive-compulsive disorder by increasing the response of the serotonin 5-HT1A receptor , that is, the active substance isreceptor agonist . Researchers claim that DSP-1181 is one of the most promising existing OCD treatments.

Representative of Sumitomo Dainippon Pharma in the person of the chief executive officer of the company Toru Kimura speaks of the latest development: “We are very excited about the results of a joint study that allowed us to develop a candidate compound in such a short time. Our experience in finding new drugs based on GPCR monoamines, together with AI capabilities, allowed us to work efficiently and ensure a successful result. “We will continue to work hard to ensure that our medicine passes clinical trials and reaches patients as soon as possible.”

Unfortunately, representatives of Exscientia did not provide any technical details of the development in a press release, however, the following picture can be drawn up from fragments of individual phrases:

  • neural network was used;
  • Japanese company SDP provided an array of tagged data for training and network operation, as they have “experience in finding drugs based on GPCR monoamines ( monoamine neurotransmitters )”;
  • the neural network was engaged in mechanical enumeration of candidate compounds for the active substance, after which the generated data array was checked by pharmaceutical company scientists;
  • there is nothing breakthrough in technology itself.

It is worth noting that for all the banality of the process of searching for the active substance in the described case (and filtering a large amount of data using machine learning is now used in many fields, from mathematics and astrophysics, to oil production and exploration), the very fact that the formula of the active substance of the drug from such an unpleasant neurological disease as OCD, was originally bred by the machine – is impressive. The most important thing that Sumitomo Dainippon Pharma and Exscientia have done is to expand the horizon of the field of application of modern computers and pharmaceutical power.

With successful clinical trials, Sumitomo Dainippon Pharma and Exscientia are likely to be among the first companies to use the neural network and so quickly receive the active drug substance for a wide range of consumers.